The presence of MET gene amplification in combination with acquire of function drug sensitive EGFR mutations could with each other result in cellular alterations that confer enhanced fitness to cells bearing both alterations. Nevertheless, other mechanisms could contribute to condition progression in such patients.
Nevertheless, study has also shown that cultured cell lines containing precisely the same EGFR genetic lesions present in human tumors can undergo cell cycle arrest or apoptosis when subjected histone deacetylase inhibitor to EGFR inhibition, even under otherwise optimal conditions. This phenomenon, termed oncogene addiction, applies to all clinical scenarios in which cancer cells appear to depend on a single overactive oncogene for their proliferation and survival. For c MET, further consideration needs to be given to the fact that genetic alterations of the kinase can induce oncogene addiction and therefore possibly aid prediction of therapeutic responsiveness. Importantly, research from Comoglio and colleagues has highlighted that preclinical investigations of developmental c MET inhibitors appear to utilize a vast array of differing cell lines, most of which tend not to be genetically characterized.
In order to identity potentially responsive tumors, PARP the different roles that cMET can play in malignant transformation and progression warrant further research. The prevalence of HGF/c MET pathway activation in human malignancies has driven a rapid growth in cancer drug development programs, with several new drugs targeting c MET showing great promise. Several c MET inhibitors are now under evaluation in clinical trials, and the interest around these compounds has consistently increased since an interaction between EGFR and c MET was observed. Clinical trials with these agents will hopefully validate positive observations from preclinical studies. c MET inhibitor agents under development include compounds that directly inhibit HGF and/or its binding to c MET, antibodies targeted at c MET, and small molecule c MET TKIs.
If the ongoing development of c MET inhibitors is to result in a clinically useful therapeutic approach, an absolute requirement is the definition of a target patient population and a practical but analytically validated histone deacetylase inhibitor method to identify them in a clinical context.
Wednesday, February 20, 2013
Professional Who Seems To Be Afraid Of histone deacetylase inhibitor IEM 1754
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